Clinical Trial Design &
From Protocols to Patients
Accelerated
Therapeutic science is advancing at an unprecedented rate, rising to the unmet medical needs of patients worldwide. However, managing increasing clinical trial complexity, patient recruitment and retention challenges, and the ever-changing regulatory landscape requires a different kind of clinical trial partner. REV Clinical’s science-forward thinking, ongoing executive-level, hands-on involvement, and a culture of accountability and responsiveness effectively address the clinical trial challenges faced by today’s therapeutic developers
Clinical Trial Design
& Protocol
Development
REV designs pragmatic, regulator-ready trials that anticipate operational challenges. Our interdisciplinary team models endpoints, powers sample size, and aligns inclusion/exclusion with real-world feasibility. We review, adapt, or author comprehensive protocols and study plans, which translates strategy into clear, actionable documents that accelerate approvals and enable faster first-patient-in. Finally, potential investigators review our study designs and protocols to ensure smooth operational conduct.
Pre-Study Rigor,
Fast Starts, Fewer
Change Orders
For REV, rapid study initiation, successful onboarding, and studies with dramatically fewer change orders are rooted in our rigor in the project bidding stage. In some cases, even before a contract is signed, cross-functional medical and feasibility teams build and pressure-test the plan to ensure assumptions are accurate, timelines are met, and change orders become the exception, not the rule.
Clinical Due Diligence
Our clinicians dissect the mechanism of action, endpoints, inclusion/exclusion, and areas of risk to anticipate operational hurdles early.
Real Time Feasibility Insights
We mine our indication experience, KOL input, and historical recruitment rates to select the best sites and forecast realistic enrollment rates.
Evidence-Based Budgeting
Our analysis provides a clear-eyed view of study challenges, enabling us to model timelines and costs to create a budget you can trust.
Rapid Onboarding & Study Starts
All learnings from the bidding stage are transferred to our project management team, enabling the successful execution of clinical trials to commence from the outset. Because sites were engaged during the feasibility phase, study sponsors and REV have the foundation needed to train sites and enroll patients collaboratively.
Patient
Recruitment
Prioritizing Holistic Clinical Trial Success
Many specialized clinical trial patient recruitment organizations measure their success by the number of patients recruited rather than by the quality of those recruited. In contrast, REV recruits with a relentless focus on holistic study success.
We begin by collaborating with our sponsor to define a target patient profile, including patient type, inclusion and exclusion criteria, and other relevant factors. Then, by leveraging our partnerships with more than 500+ clinical sites and their associated physicians, we examine their patient populations and make informed decisions regarding the study’s suitability, supporting the site’s patient recruitment efforts in every way possible.
Clinical Oversight
That De-Risks
Your Study
Rigor, dedication, and clinical trial excellence support your sites, protect your data, and keep your study on track. REV is dedicated to excellence in clinical trial management and monitoring.
01
Standardized templates, clear budgets, and fast turnarounds ensure contracts move efficiently. Milestone-based payments and proactive tracking ensure sites are paid on time, sustaining engagement and enrollment.
02
From the first site kick-off through the last patient’s final visit, REV Clinical coordinates every step, including investigational product accountability, team training, deviation management, trial master file upkeep, and trial closeout.
03
Hybrid oversight tailored to your protocol: centralized data review, remote source data verification and review, and virtual touchpoints that reduce site burden while maintaining vigilance and velocity.
04
We focus on what matters most, monitoring key risk indicators, trend signals, quality tolerance limits, and other critical metrics. By thoroughly defining these signals before the study starts, we can proactively collaborate, communicate, and take action with our sponsor clients before challenges become problems.
05
We support sites by conducting mock audits, developing CAPAs, and providing on-demand coaching to help them navigate sponsor or regulatory inspections with confidence.
Operations in
Strategic Clinical
Hubs
United States
- Robust regulatory framework
- Strong ethical oversight
- Leading KOLs & clinicians
- Large & diverse patient population
India
- Large patient population
- Rapid recruitment
- Cost-effective
- Established research infrastructure
Australia
- Flexible regulatory environment
- Cost-effective
- Leading scientists & clinicians
- R&D rebates
Risk Mediated
Clinical Trial
Supplies
Management
Moving investigational products across borders while protecting integrity, complying with regulations, and meeting timelines is difficult, but REV rises to the challenge. We pair seasoned project managers with established global distribution partners to seamlessly transport finished drug products worldwide from the first shipment to final reconciliation.
- Risk & timeline management
We conduct worst-case scenario planning for customs holds, seasonal disruptions, manufacturing challenges, and other difficulties to keep milestones and budgets on track. - Regulatory pathway & clearances
Map required local approvals and documentation so the product can legally enter/exit each country. - Finished product strategy
Plan for in-market processing (fill/finish, packaging, labeling) or direct-to-site distribution of finished dosage forms. - End-to-end chain of custody
Working with partners, we manage temperature-controlled transport, custody logs, and reconciliation to maintain product integrity and audit readiness.
Let’s Move Your Study Forward
Interested in connecting with REV Clinical’s team of interdisciplinary experts to answer questions, take action on your RFP, and clearly define next steps?